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DC Field | Value | Language |
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dc.contributor.author | Shabbir, Maryam | - |
dc.contributor.author | Ali, Sajid | - |
dc.contributor.author | Raza, Moosa | - |
dc.contributor.author | Sharif, Ali | - |
dc.contributor.author | Akhtar, Furoan Muhammad | - |
dc.contributor.author | Manan, Abdul | - |
dc.contributor.author | Fazli, Ali Raza | - |
dc.contributor.author | Younas, Neelofar | - |
dc.contributor.author | Manzoor, Iqra | - |
dc.date.accessioned | 2021-04-19T09:06:50Z | - |
dc.date.available | 2021-04-19T09:06:50Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.citation | Shabbir M, Ali S, Raza M, Sharif A, Akhtar FM, Manan A, Fazli AR, Younas N, Manzoor I. EFFECT OF HYDROPHILIC AND HYDROPHOBIC POLYMER ON IN VITRO DISSOLUTION AND PERMEATION OF BISOPROLOL FUMARATE THROUGH TRANSDERMAL PATCH. Acta Pol Pharm. 2017 Jan;74(1):187-197. PMID: 29474775. | en_US |
dc.identifier.issn | ISSN 0001-6837 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/1230 | - |
dc.description | https://pubmed.ncbi.nlm.nih.gov/29474775/ | en_US |
dc.description.abstract | A matrix transdermal patch of bisoprolol fumarate was formulated with different concentrations of Eudragit RS100 and Methocel E5 with PEG 400 as plasticizer by solvent evaporation technique. Tween 80 was added to the optimized patch to evaluate the effect of permeation enhancer at different concentration through the excised rabbitís skin. The patches were analyzed for weight variation, drug content, swelling index, erosion studies, moisture content, moisture uptake, water vapor transmission rate (WVTR) and water vapor permeabil ity (WVP). In vitro dissolution test was carried out in USP dissolution apparatus V to select the optimized for mulation. In vitro skin permeation studies were done in Franz diffusion cell using rabbit skin as a model mem brane. The cumulative drug release and flux were determined to compare the result of test patches with a con trol patch. The greatest enhancement ratio (ER) was obtained in F03-PE with 30% Tween 80. F03-PE seemed to follow zero order kinetics with super case II mechanism of drug release. Statistical ANOVA suggested that there was a significant difference in formulations, steady flux and cumulative permeation rate at different Tween 80 concentrations. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pubmed | en_US |
dc.relation.ispartofseries | Acta Pol Pharm . 2017 Jan;74(1):187-197.; | - |
dc.subject | transdermal patch | en_US |
dc.subject | Eudragit RS100, | en_US |
dc.subject | kinetics, | en_US |
dc.subject | Methocel E5, | en_US |
dc.subject | Tween 80, | en_US |
dc.title | EFFECT OF HYDROPHILIC AND HYDROPHOBIC POLYMER ON IN VITRO DISSOLUTION AND PERMEATION OF BISOPROLOL FUMARATE THROUGH TRANSDERMAL PATCH | en_US |
dc.type | Article | en_US |
Appears in Collections: | Pharmacy Department |
Files in This Item:
File | Description | Size | Format | |
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EFFECT OF HYDROPHILIC AND HYDROPHOBIC POLYMER ON IN VITRO.pdf | 216.02 kB | Adobe PDF | View/Open |
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