Please use this identifier to cite or link to this item:
http://digitalrepository.fccollege.edu.pk/handle/123456789/1232
Title: | DEVELOPMENT OF COMPRESSED COATED POLYPILL WITH MUCOADHESIVE CORE COMPRISING OF ATORVASTATIN/CLOPIDOGREL/ASPIRIN USING COMPRESSION COATING TECHNIQUE |
Authors: | Shahid, Nabeel Adnan, Sherjeel Farooq, Muhammad Ali, Sajid Shabbir, Maryam Masood, Zeeshan Waqar, Kiran Saleem, Hamad Gill, Shoaib Ali Ali, Tabish |
Keywords: | polymers compression coating technique , kinetics, mucoadhesive, polypill, |
Issue Date: | Mar-2017 |
Publisher: | Pubmed |
Citation: | Shahid N, Adnan S, Farooq M, Ali S, Shabbir M, Masood Z, Waqar K, Saleem H, Gill SA, Ali T. DEVELOPMENT OF COMPRESSED COATED POLYPILL WITH MUCOADHESIVE CORE COMPRISING OF ATORVASTATIN/CLOPIDOGREL/ASPIRIN USING COMPRESSION COATING TECHNIQUE. Acta Pol Pharm. 2017 Mar;74(2):477-487. PMID: 29624252. |
Series/Report no.: | Acta Pol Pharm . 2017 Mar;74(2):477-487.; |
Abstract: | The study was conducted to formulate and assess a novel polypill comprising of atorvastatin calci um (ATVC), clopidogrel bisulfate (CLB) and aspirin (ASP) which, after in vivo correlation, can be intended for use in hyperlipidemic chronic heart disease patients. Polypill was made by the compression coating technique (CCT) with multiple active ingredients along with different concentrations of mucoadhesive and sustained release polymers, i.e., Carbopol 934 (CAB), Methocel k15 (MTH) and sodium carboxymethyl cellulose (NaCMC). The effect of different concentration of polymers on physical properties, wash off time, mucoadhe sion strength, swelling behavior, surface pH and drug release kinetics were investigated. In vitro drug release studies showed that combination of CAB-NaCMC (1 : 1) retarded drug release up to 96.7 ± 1.15%, while com bination of CAB-MTH and MTH-NaCMC retarded drug release up to 81.9 ± 1.5% and 101.4 ± 1.3%, respec tively, at the same polymer concentration. Core enteric coated tablet of ATVC (K11) was compressed over with CLB and ASP granules with the help of CCT and produced the desired results with zero order release rate thus indicating successful formulation of proposed polypill. |
Description: | https://pubmed.ncbi.nlm.nih.gov/29624252/ |
URI: | http://localhost:8080/xmlui/handle/123456789/1232 |
ISSN: | ISSN 0001-6837 |
Appears in Collections: | Pharmacy Department |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
DEVELOPMENT OF COMPRESSED COATED POLYPILL WITH.pdf | 184.14 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.