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DC Field | Value | Language |
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dc.contributor.author | Rehman, Atta Ur | - |
dc.contributor.author | Liaquat, Manal | - |
dc.contributor.author | Asghar, Rabia | - |
dc.contributor.author | Syed, Nawazish-i-Husain | - |
dc.date.accessioned | 2021-04-22T12:21:08Z | - |
dc.date.available | 2021-04-22T12:21:08Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Rehman AU, Liaquat M, Asghar R, Syed N. Evaluation of methanolic extract of Phragmites karka on carbon tetrachloride-induced liver fibrosis in rat. Bangladesh J Pharmacol. 2017; 12: 276-81. | en_US |
dc.identifier.issn | ISSN: 1991-0088 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/1248 | - |
dc.description | https://www.banglajol.info/index.php/BJP/article/view/32127 | en_US |
dc.description.abstract | Phragmites karka has been reported for its anti-inflammatory and analgesic activities. Here, extracts of leaf and rhizome of the plant were individually investigated in CCl4-induced hepatofibrosis in male Wistar rats by adminis tering CCl4 intraperitoneally biweekly for 6 weeks. Afterwards the animals were investigated for liver fibrosis at biochemical, molecular and histological levels, and it showed a profound increase (p<0.001) in elevation of serum levels of transaminases, DŽ-glutamyl transpeptidase, mRNA expression of ǂ smooth muscle actin, collagen and transforming growth factor beta (TGFǃ), and extracellular matrix deposition and perilobular necrosis. Both extracts markedly (p<0.001) decreased the elevated levels of these markers. Histopathological investigations also substantiated the above results by exhibiting a decreased in extracellular matrix deposition in post-treatment animals. In conclusion, both extracts had substantially modified the bioche mical and molecular markers of liver fibrosis, in addition to histological improvement in architecture of liver | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bangladesh journal of pharmacology | en_US |
dc.relation.ispartofseries | Bangladesh J Pharmacol 2017; 12: 276-281; | - |
dc.subject | Evaluation | en_US |
dc.subject | liver fibrosis | en_US |
dc.subject | rats | en_US |
dc.subject | CCL4 | en_US |
dc.title | Evaluation of methanolic extract of Phragmites karka on carbon tetrachloride-induced liver fibrosis in rat | en_US |
dc.type | Article | en_US |
Appears in Collections: | Pharmacy Department |
Files in This Item:
File | Description | Size | Format | |
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20160701 BJP Evaluation_of_methanolic_extract_of_Phragmites_kar ok.pdf | 1.18 MB | Adobe PDF | View/Open |
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