Straightforward and direct access to b-seleno- amines and sulfonylamides via the controlled addition of phenylselenomethyllithium (LiCH2SePh) to imines

Please use this identifier to cite or link to this item: http://digitalrepository.fccollege.edu.pk/handle/123456789/1282

Title:	Straightforward and direct access to b-seleno- amines and sulfonylamides via the controlled addition of phenylselenomethyllithium (LiCH2SePh) to imines
Authors:	Senatore, Raffaele Malik, Monika Touqeer, Dr. Saad Listro, Roberta Collina, Simona Holzer, Wolfgang Pace, Vittorio
Keywords:	amines sulfonylamides direct access
Issue Date:	18-Dec-2020
Publisher:	ELSEVIER
Citation:	Raffaele Senatore, Monika Malik, Saad Touqeer, Roberta Listro, Simona Collina, Wolfgang Holzer, Vittorio Pace, Straightforward and direct access to β-seleno- amines and sulfonylamides via the controlled addition of phenylselenomethyllithium (LiCH2SePh) to imines, Tetrahedron, Volume 76, Issue 51, 2020, 131220, ISSN 0040-4020, https://doi.org/10.1016/j.tet.2020.131220.
Series/Report no.:	Volume 76, Issue 51, 2020, 131220,;
Abstract:	The transfer of a a-methyl phenylseleno carbanion to variously functionalized N-aryl and N-sulfonyl imines is reported. The fast selenium-lithium exchange conducted on a diselenoacetal with n-BuLi en ables the generation of the attacking homologative nucleophile under chemoselective conditions pre serving concomitant potentially sensitive functionalities to the lithiating conditions. Uniformly high yields were observed, thus establishing a valuable and conceptually simple approach to the title compounds.
Description:	https://www.sciencedirect.com/science/article/abs/pii/S0040402020303550
URI:	http://localhost:8080/xmlui/handle/123456789/1282
Appears in Collections:	Pharmacy Department

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