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DC Field | Value | Language |
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dc.contributor.author | Khan, Safeer | - |
dc.contributor.author | Khan, Shafi Ullah | - |
dc.date.accessioned | 2022-04-22T09:56:33Z | - |
dc.date.available | 2022-04-22T09:56:33Z | - |
dc.date.issued | 2020-05-21 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/1524 | - |
dc.description.abstract | What is known and objective: The imbalance in serum potassium caused by laxatives can negatively affect the cardiovascular system, leading to life-threatening conse- quences. Our objective was to evaluate the reported evidence of adverse events re- lated to the cardiac system due to laxative-induced hypokalaemia from case reports. Methods: A systematic electronic literature search of PubMed, Embase, the Cochrane Library and Science Direct was conducted for the period 1995-2019. In these data- bases, search terms describing hypokalaemia and cardiotoxicity were combined with the term laxative use. Results and discussion: Over the 23 years, 27 incidents were identified in 12 coun- tries. There were 19 female and eight male patients, with ages ranging from 1 month to 93 years. The frequency of reported cases according to severity was the following: severe hypokalaemia 48%, moderate hypokalaemia 44.4% and mild hypokalaemia 7.4%. In 70% of patients, the effect of laxative on the heart was typical hypokalaemic electrographic changes, 7.4% showed abnormal changes in cardiac rhythm, whereas in 18.5%, the cardiotoxicity observed was a very serious kind. Two patients died due to severe cardiac effects. What is new and conclusion: The laxatives—along with the involvement of some other contributing factors—caused mild-to-severe hypokalaemic cardiotoxicity. These fac- tors were non-adherence of the patient to the recommended dosage, laxative abuse, drug-drug and drug-disease interactions, non-potassium electrolyte imbalances and the use of herbal laxatives. We recommend that laxatives and aggravating factors should be taken into account in the assessment of patients with suspected hypoka- laemic cardiotoxicity. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Research Gate | en_US |
dc.subject | adverse drug event, cardiotoxicity, hypokalemia, laxative | en_US |
dc.title | Adverse drug event of hypokalemia-induced cardiotoxicity secondary to the use of laxatives: A systematic review of case reports | en_US |
Appears in Collections: | Pharmacy Department |
Files in This Item:
File | Description | Size | Format | |
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ADR by Laxatives (Safeer Khan).pdf | 809.15 kB | Adobe PDF | View/Open |
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