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Title: | Preparation, characterization and biodistribution of the 99mTc-salicylidenediamine-N-dione complex |
Authors: | Javed, M. Khan, I. U. Naeem, M. Asghar, S. Naseer, H. Iqbal, Mohammad S. Anwar, J. |
Issue Date: | 23-May-2007 |
Publisher: | Journal of Radioanalytical and Nuclear Chemistry |
Citation: | Javed, M., et al. "Preparation, characterization and biodistribution of the 99m Tc-salicylidenediamine-N-dione complex." Journal of Radioanalytical and Nuclear Chemistry 277.2 (2008): 303-309. |
Abstract: | A tetradentate set of N2O2 salicylaldehyde-amine-N-dione Schiff base was prepared by condensation with salicylaldehyde, ethylenediamine, 2,4- dione and reduction with NaBH4. The ligand system was characterized by 1H-NMR and FT-IR spectroscopy and HPLC. Radiolabeling studies of the 99mTc-complex were performed using stannous ions as the reducing agent. The purity of the complex was determined by ascending solvent system on paper chromatography and instant thin-layer chromatography (ITLC). The yield of the complex was >90%. Biodistribution of the 99mTc complex of the precursor was studied in rabbits. A significant uptake and retention of injected activity was observed in the liver and cleared through the bladder. A faint activity was also observed in kidneys. These results indicate that the proposed system may be suitable for development of a liver/spleen imaging agent for future clinical applications. |
URI: | http://202.142.177.21/handle/123456789/2239 |
Appears in Collections: | Chemistry Department |
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JRNC2008.pdf | 622.56 kB | Adobe PDF | View/Open |
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