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http://digitalrepository.fccollege.edu.pk/handle/123456789/2260Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Saeed Iqbal, Mohammad | - |
| dc.contributor.author | Bukhari, Iftikhar | - |
| dc.contributor.author | Arif, Muhammad | - |
| dc.date.accessioned | 2024-05-25T19:48:56Z | - |
| dc.date.available | 2024-05-25T19:48:56Z | - |
| dc.date.issued | 2005-07 | - |
| dc.identifier.citation | Iqbal, Mohammad & Bukhari, Iftikhar & Arif, Muhammad. (2005). Preparation, characterization and biological evaluation of copper(II) and zinc(II) complexes with Schiff bases derived from amoxicillin and cephalexin. Applied Organometallic Chemistry. 19. 864 - 869. 10.1002/aoc.918. | en_US |
| dc.identifier.other | Doi | - |
| dc.identifier.uri | http://202.142.177.21/handle/123456789/2260 | - |
| dc.description | The wide use of antibiotics in man and animals and their extensive use in areas other than the treatment and prophylaxis of disease have resulted in a serious problem of drug resistance. More and more bacterial strains have become resistant to the available drugs. Various strategies have been worked out and tried to cope with the resistance problem and enhance the activity, or broaden the spectrum of the drugs.1 Preparation of different synthetic derivatives of antibiotics based on structure–activity relationships has been one of the best approaches. In this study we have attempted to widen the scope of derivatization by providing more flexibility through Schiff base formation with the drug substances containing –NH2 groups and complexation with metal ions. The Schiff base structures provide for a greater choice and flexibility, and complexation with metal ions adds to the stability and versatility of the molecule. The drug molecules used in the present study contain –NH2, –COOH and other donor groups; construction of molecular models indicates that the structures are suitable for chelate formation. | en_US |
| dc.description.abstract | Copper(II) and zinc(II) complexes of Schiff bases obtained by condensation of amoxicillin and cephalexin with salicylaldehyde/pyridoxal were prepared and characterized by microanalytical, thermogravimetric, magnetic and spectroscopic data. All the complexes were found to be sixcoordinate and containing two water molecules. The electron paramagnetic resonance spectral lines exhibited rhombic distortion fromaxial symmetry,with g > g⊥ > ge, in the copper(II) complexes. The geometry of the zinc(II) complexes appears to be octahedral. All the compounds under investigation showed antibacterial activity. The antibacterial activity showed the following trend: copper(II) complexes > zinc(II) complexes > Schiff base ligands > parent drugs. The copper(II) complexes with the Schiff bases derived fromcephalexin showed substantially enhanced activity against Pseudomonas aeruginosa compared with the parent drug. All the copper complexes were also found to be active against kaolin paw oedema, whereas the parent drugs were inactive. Copyright 2005 John Wiley & Sons, Ltd. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | researchgate.net | en_US |
| dc.subject | copper complexes; zinc complexes; antibacterials; Schiff base complexes; cephalosporins | en_US |
| dc.title | Preparation, characterization and biological evaluation of copper(II) and zinc(II) complexes with Schiff bases derived from amoxicillin and cephalexin | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Chemistry Department | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| AOC2005.pdf | 113.12 kB | Adobe PDF | View/Open |
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