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Title: | A Spectroscopic Study of Interaction of Auricyanide with N-Acetylcysteine |
Authors: | Saeed Iqbal, Mohammad Frank Shaw III, C. G. T. Kazimi, Syed |
Keywords: | Auricyanide . N-acetylcysteine . Electrospray ionization mass spectroscopy (ESI-MS) . Rheumatoid arthritis . UV-vis spectroscopy |
Issue Date: | 14-Sep-2018 |
Publisher: | researchgate.net |
Citation: | Kazimi, Syed & Iqbal, Mohammad & late, C.. (2018). A Spectroscopic Study of Interaction of Auricyanide with N-Acetyl-cysteine. Biological Trace Element Research. 183. 183-401. 10.1007/s12011-017-1149-1. |
Abstract: | Interaction of auricyanide, an important metabolite of anti-arthritic gold-based drug auranofin, was studied in vitro with a pharmacologically active ligand Nacetylcysteine with a view to understand reactivity of gold in vivo. Formation of reduction product aurocyanide occurred through mono- and di-N-acetylcysteine-substituted intermediates. The product and intermediates were identified and monitored spectrophotometrically and by electrospray ionization mass spectrometry. This study suggests successive substitution with N-acetylcysteine through trans effect. At equimolar concentrations of auricyanide and N-acetylcysteine, only mono-substituted mixed-ligand complex was formed. Substitution of the data obtained to various kinetic models suggested that the reaction orders are 0.6 in terms of Nacetylcysteine, 1.5 in terms of auricyanide, and 2 overall. The intermediates detected in this work may help to synthesize more effective and less toxic gold drugs. |
Description: | Use of gold drugs in treatment of rheumatoid arthritis, tuberculosis, endocarditis, and syphilis, commonly known as chrysotherapy, is well documented [1–4]. In rheumatoid arthritis, the gold drugs have been considered as disease modifying. The first-generation gold drugs were injectables like Solganal (gold thioglucose, AuSTg) and Myochrysine (gold sodium thiomalate, AuSTm), whereas the second-generation drug auranofin, (2,3,4,6-tetra-Oacetyl- β-1-D-thioglucopyranosato-S-(triethylphosphine) gold(I), abbreviated here as Et3PAuSATg, is administered orally. With the advent of more effective and less toxic anti-inflammatory drugs, their use has become very limited. However, there have been new indications in cancer and parasitic diseases [5–7]. |
URI: | http://202.142.177.21/handle/123456789/2269 |
Appears in Collections: | Chemistry Department |
Files in This Item:
File | Description | Size | Format | |
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BTER2018N-AcCys.pdf | 883.8 kB | Adobe PDF | View/Open |
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