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http://digitalrepository.fccollege.edu.pk/handle/123456789/2325
Title: | Evaluation of hot-water extracted arabinoxylans from ispaghula seeds as drug carriers |
Authors: | S. Iqbal, Mohammad Akbar, Jamshed A. Hussain, Muhammad Saghir, Shazia Sher, Muhammad |
Keywords: | Ispaghula gel Arabinoxylans Hydrogels Sustained release Controlled drug delivery |
Issue Date: | Jan-2011 |
Publisher: | researchgate.net |
Citation: | Iqbal, Mohammad & Akbar, Jamshed & Hussain, Muhammad & Saghir, Shazia & Sher, Muhammad. (2011). Evaluation of hot-water extracted arabinoxylans from ispaghula seeds as drug carriers. Carbohydrate Polymers. 83. 1218-1225. 10.1016/j.carbpol.2010.09.024. |
Abstract: | This work evaluates the potential of a hot water extracted arabinoxylan from ispaghula (Plantago ovata) seeds as a safe, effective and economical drug carrier. In thermal analysis integral procedural decomposition temperature and comprehensive index of thermal stability were found to be 308 ◦C and 0.47 respectively. Gel permeation chromatography showed the existence of two components in the fraction. Atomic force microscopy indicated a surface having nanostructure. The tablets incorporating caffeine and diclofenac sodium formulated by the use of arabinoxylan exhibited sustained release profiles in various media. A pH-independent release pattern was observed for caffeine, while for diclofenac sodium the profile was found to be pH-dependent. The arabinoxylan provided a better sustained release as compared with that of Voltral®, a standard diclofenac sodium preparation. The release data suggest Power Law an appropriate model for this system. |
URI: | http://digitalrepository.fccollege.edu.pk/handle/123456789/2325 |
Appears in Collections: | Chemistry Department |
Files in This Item:
File | Description | Size | Format | |
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CP2011(1).pdf | 639.51 kB | Adobe PDF | View/Open |
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