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DC Field | Value | Language |
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dc.contributor.author | Iqbal, Mohammad S. | - |
dc.contributor.author | Kazimi, Syed | - |
dc.contributor.author | Shaw, Frank | - |
dc.date.accessioned | 2019-04-08T05:51:21Z | - |
dc.date.available | 2019-04-08T05:51:21Z | - |
dc.date.issued | 2017-09-14 | - |
dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/475 | - |
dc.description.abstract | Interaction of auricyanide, an important metabolite of anti-arthritic gold-based drug auranofin, was studied in vitro with a pharmacologically active ligand Nacetylcysteine with a view to understand reactivity of gold in vivo. Formation of reduction product aurocyanide occurred through mono- and di-N-acetylcysteine-substituted intermediates. The product and intermediates were identified and monitored spectrophotometrically and by electrospray ionization mass spectrometry. This study suggests successive substitution with N-acetylcysteine through trans effect. At equimolar concentrations of auricyanide and N-acetylcysteine, only mono-substituted mixed-ligand complex was formed. Substitution of the data obtained to various kinetic models suggested that the reaction orders are 0.6 in terms of Nacetylcysteine, 1.5 in terms of auricyanide, and 2 overall. The intermediates detected in this work may help to synthesize more effective and less toxic gold drugs. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Cross Mark | en_US |
dc.subject | Chemistry | en_US |
dc.title | A Spectroscopic Study of Interaction of Auricyanide with N-Acetylcysteine | en_US |
dc.type | Article | en_US |
Appears in Collections: | Chemistry Department |
Files in This Item:
File | Description | Size | Format | |
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BTER2018.pdf | 883.8 kB | Adobe PDF | View/Open |
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