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http://digitalrepository.fccollege.edu.pk/handle/123456789/543Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Arshad, Laiba | - |
| dc.contributor.author | Jantan, Ibrahim | - |
| dc.contributor.author | Haque, Md. Areeful | - |
| dc.contributor.author | Bukhari, Syed Nasir Abbas | - |
| dc.date.accessioned | 2019-04-12T05:00:02Z | - |
| dc.date.available | 2019-04-12T05:00:02Z | - |
| dc.date.issued | 2017-01-30 | - |
| dc.identifier.uri | http://localhost:8080/xmlui/handle/123456789/543 | - |
| dc.description.abstract | Theimmunesystemiscomplexandpervasiveasitfunctionstopreventorlimitinfectionsinthehumanbody.Inahealthyorganism,theimmunesystemandtheredoxbalanceofimmunecellsmaintainhomeostasiswithinthebody.Thefailuretomaintainthebalancemayleadtoimpairedimmuneresponseandeitheroveractivityorabnormallylowactivityoftheimmunecellsresultinginautoimmuneorimmunedeficiencydiseases.Compoundscontaininga,b-unsaturatedcarbonyl-basedmoietiesareoftenreactive.Thereactivityofthesegroupsisresponsiblefortheirdiversepharmacologicalactivities,andthemostimportantandwidelystudiedincludethenaturalcompoundscurcumin,chalcone,andzerumbone.Numerousstudieshaverevealedthemainlyimmunosuppressiveandanti-inflammatoryactivitiesoftheaforesaidcompounds.Thisreviewhighlightsthespecificimmunosuppressiveeffectsofthesenaturala,b-unsaturatedcarbonyl-basedcompounds,andtheiranalogsandderivativesondifferenttypesofimmunecellsoftheinnate(granulocytes,monocytes,macrophages,anddendriticcells)andadaptive(Tcells,Bcells,andnaturalkillercells)immunesystems.Theinhibitoryeffectsofthesecompoundshavebeencomprehensivelystudiedonneutrophils,monocytesandmacrophagesbuttheireffectsonTcells,Bcells,naturalkillercells,anddendriticcellshavenotbeenwellinvestigated.Itisofparamountimportancetocontinuegeneratingexperimentaldataonthemechanismsofactionofa,b-unsaturatedcarbonyl-basedcompoundsonimmunecellstoprovideusefulinformationforensuingresearchtodiscovernewimmunomodulatingagents. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | Frontiers in Pharmacology | en_US |
| dc.subject | Pharmacy | en_US |
| dc.title | ImmunosuppressiveEffectsofNaturala,b-UnsaturatedCarbonyl-BasedCompounds,andTheirAnalogsandDerivatives,onImmuneCells:AReview | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Pharmacy Department | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| frontiers in pharmacolog alpha beta.pdf | 1.4 MB | Adobe PDF | View/Open |
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