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Title: | Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation |
Authors: | Mehnaz, Samina Chaudhury, Chaity Kim, Joghan Wani, Manzoor A. M Oberyszyn, Tatiana Bronson, C L Mohanty, Sudharsi L Hayton, William Robinson, John M Anderson, Clark L |
Keywords: | Animal Feed Mice Hemochromatosis Protein Histocompatibility Antigens Class I Immunoglobulin A / metabolism Kinetics Membrane Proteins / deficiency* Male Mice, Inbred C57BL Mice Knockout Proteinuria Reference values Transferrin / metabolism* Transferrin / pharmacokinetics |
Issue Date: | 1-Dec-2006 |
Publisher: | Journal of Nutrition, PubMed.gov, National Library of Medicine, National Center for Biotechnology Information |
Citation: | Chaudhury C, Kim J, Mehnaz S, Wani MA, Oberyszyn TM, Bronson CL, Mohanty S, Hayton WL, Robinson JM, Anderson CL. Accelerated transferrin degradation in HFE-deficient mice is associated with increased transferrin saturation. J Nutr. 2006 Dec;136(12):2993-8. doi: 10.1093/jn/136.12.2993. PMID: 17116709. |
Series/Report no.: | 2006 Dec;136(12):2993-8.;PMID: 17116709 |
Abstract: | HFE, a major histocompatibility complex class I-related protein, is implicated in the iron overload disease, hereditary hemochromatosis. Whereas patients with hereditary hemochromatosis have low serum transferrin levels, little is known about transferrin turnover in HFE deficiency states. We injected mice intravenously with radioiodinated transferrin and compared plasma transferrin decay and steady-state endogenous transferrin concentration in the plasma between HFE-deficient and wild-type C57BL/6 mouse strains. HFE-deficient mice degraded transferrin faster than normal (P < 0.001) and had lower plasma transferrin concentrations (P < 0.001). Both HFE-deficient and wild-type mice were then fed diets with 3 different iron concentrations that we designated deficient (2-5 mg/kg of iron), control (0.2 g/kg), and overload (20 g/kg) for 6 wk immediately after weaning to create a range of serum iron concentrations and resultant transferrin saturations ranging from 16 to 78%. We found an inverse correlation between transferrin saturation and transferrin half-life (P < 0.0001, r = -0.839) for both HFE-deficient and wild-type mice, which suggests that HFE does not have a direct effect on transferrin catabolism; rather, HFE may influence transferrin half-life indirectly through its effect on transferrin saturation, which in turn enhances transferrin decay in HFE-deficient mice. |
Description: | Publication types Research Support, N.I.H., Extramural |
URI: | http://localhost:8080/xmlui/handle/123456789/1032 |
Appears in Collections: | School of Life Sciences |
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transferrin.journal of nutrition.pdf | 159.22 kB | Adobe PDF | View/Open |
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