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Title: | The contribution of genome mining strategies to the understanding of active principles of PGPR strains |
Authors: | Paterson, Julia Jahanshah, , Ghazaleh Li, , Yan Wang, , Qi Mehnaz, Samina Gross, Harald |
Keywords: | PGPR biocontrol strains rhizosphere bacteria; genome mining Pseudomonas Bacillus |
Issue Date: | 16-Dec-2016 |
Publisher: | Federation of European Microbiological Societies |
Citation: | Paterson J, Jahanshah G, Li Y, Wang Q, Mehnaz S, Gross H. The contribution of genome mining strategies to the understanding of active principles of PGPR strains. FEMS Microbiol Ecol. 2017 Mar;93(3):fiw249. doi: 10.1093/femsec/fiw249. Epub 2016 Dec 15. PMID: 27986826. |
Series/Report no.: | Paterson J, Jahanshah G, Li Y, Wang Q, Mehnaz S, Gross H. The contribution of genome mining strategies to the understanding of active principles of PGPR strains. FEMS Microbiol Ecol. 2017 Mar;93(3):fiw249. doi: 10.1093/femsec/fiw249. Epub 2016 Dec 15. PMID: 27986826.; |
Abstract: | Pathogenic microorganisms and insects affecting plant health are a major and chronic threat to food production and the ecosystem worldwide. As agricultural production has intensified over the years, the use of agrochemicals has in turn increased. However, this extensive usage has had several detrimental effects, with a pervasive environmental impact and the emergence of pathogen resistance. In addition, there is an increasing tendency among consumers to give preference to pesticide-free food products. Biological control, through the employment of plant growth-promoting rhizobacteria (PGPR), is therefore considered a possible route to the reduction, even the elimination, of the use of agrochemicals. PGPR exert their beneficial influence by a multitude of mechanisms, often involving antibiotics and proteins, to defend the host plant against pathogens. To date, these key metabolites have been uncovered only by systematic investigation or by serendipity; their discovery has nevertheless been propelled by the genomic revolution of recent years, as increasing numbers of genomic studies have been integrated into this field, facilitating a holistic view of this topic and the rapid identification of ecologically important metabolites. This review surveys the highlights and advances of genome-driven compound and protein discovery in the field of bacterial PGPR strains, and aims to advocate for the benefits of this strategy. |
Description: | Affiliations 1Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Tübingen, 72076 Tübingen, Germany. 2Department of Plant Pathology, China Agricultural University, Beijing 100193, P. R. China. 3Department of Biological Sciences, Forman Christian College University, Lahore 54600, Pakistan. 4Department of Pharmaceutical Biology, Pharmaceutical Institute, University of Tübingen, 72076 Tübingen, Germany harald.gross@uni-tuebingen.de. https://pubmed.ncbi.nlm.nih.gov/27986826/ |
URI: | http://localhost:8080/xmlui/handle/123456789/1094 |
Appears in Collections: | School of Life Sciences |
Files in This Item:
File | Description | Size | Format | |
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FEMS. minireview.2017.pdf | 1.42 MB | Adobe PDF | View/Open |
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