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DC Field | Value | Language |
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dc.contributor.author | Idrees, Muhammad | - |
dc.contributor.author | Rafique, Shazia | - |
dc.contributor.author | Rehman, Irshad-ur | - |
dc.contributor.author | Akbar, Haji | - |
dc.contributor.author | Yousaf, Muhammad Zubair | - |
dc.contributor.author | Butt, Sadia | - |
dc.contributor.author | Awan, Zunaira | - |
dc.contributor.author | Manzoor, Sobia | - |
dc.contributor.author | Akram, Madiha | - |
dc.contributor.author | Aftab, Mahwish | - |
dc.contributor.author | Khubaib, Bushra | - |
dc.contributor.author | Riazuddin, Sheikh | - |
dc.date.accessioned | 2023-11-23T11:17:32Z | - |
dc.date.available | 2023-11-23T11:17:32Z | - |
dc.date.issued | 2009-10-28 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | 10.11.12.71:8080/jspui/handle/123456789/1947 | - |
dc.description.abstract | Aim: To assess the association between chronic hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) in Pakistan, and the genotype distribution among these HCC patients. Methods: One hundred and sixty-one subjects with HCC were included in this study. Liver biopsy was performed on 145 of the patients; sixteen were excluded because they failed to fulfill the inclusion criteria. Qualitative polymerase chain reaction (PCR) was performed for hepatitis B virus and HCV. Samples positive for HCV RNA were genotyped using genotype-specific PCR and confirmed by HCV 5' noncoding region sequencing analysis. Results: Chronic HCV infection was identified a major risk factor (63.44% of tested HCC patients) for the development of HCC. The time from HCV infection to appearance of cancer was 10-50 years. In the HCC patient population, broader distributions of genotypes were present with genotype 3a as the predominant genotype. Using the type-specific genotyping method, we found HCV genotype 3a in 40.96%, 3b in 15.66%, 1a in 9.63%, and 1b in 2.40% of HCC tissue samples. About 28% of cases were found with mixed genotypes. Two cases were unable to be genotyped because of low viral load. Sixty-six percent of treated patients with cirrhosis had an end of treatment response, but unfortunately they relapsed quickly when the treatment was discontinued, and HCC developed during a median 3.8 years. Conclusion: There was a strong association between chronic HCV infection and HCC in Pakistan, and between HCV genotype 3a and HCC. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Beijing Baishideng BioMed Scientific and Baishideng Publishing Group | en_US |
dc.relation.ispartofseries | World Journal of Gastroenterology;Volume 15, Issue 40 | - |
dc.subject | Hepatocellular carcinoma | en_US |
dc.subject | Hepatitis C | en_US |
dc.subject | Genotyping | en_US |
dc.subject | Etiology | en_US |
dc.subject | Prevalence | en_US |
dc.title | Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience | en_US |
dc.type | Article | en_US |
Appears in Collections: | School of Life Sciences |
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File | Description | Size | Format | |
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WJG-15-5080.pdf | 726.15 kB | Adobe PDF | View/Open |
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